We'll begin with "issue" as a noun.

The first meaning refers to things like magazines and comic books that are released on a regular schedule. For example, a monthly magazine would have 12 issues every year, one for each month.
The other noun version of "issue" is quite common in business and other formal situations. It is another way to say "problem" or "difficulty." While it doesn't sound as negative as those other words, the meaning is sometimes exactly the same.

While "issue" can be a problem at work or on some kind of project, it can also refer to problems that are much more personal. It's a useful word for talking about something negative without being specific.

As a verb, "issue" has one basic meaning, which is "to give" or "to send out." This can be used in a few different ways. This formal usage is quite common when referring to official documents.
There is an adjective usage that is related to this. Something that is "standard-issue" is normal or common.

Let's finish this article with a few idioms that use "issue."
Meaning: to get upset or angry about
Meaning: to treat something very seriously
Meaning: something that is not important
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